The Protective Effect of Bosentan against Atherosclerosis in Apolipoprotein E-Deficient Mice Is Mediated by miRNA-21

Figure 4

Bosentan reduced caspase-3 expression in the aortic sinuses of ApoE^−/− mice. Immunohistochemistry staining for caspase-3 in atherosclerotic plaques from the indicated groups of mice.