The Protective Effect of Bosentan against Atherosclerosis in Apolipoprotein E-Deficient Mice Is Mediated by miRNA-21

Figure 7

Bosentan enhanced the expression of miRNA-21 in ApoE^−/− mice. A real-time qPCR analysis of miRNA-21 expression in atherosclerotic plaque from the indicated groups of mice. The miRNA abundance in each group was normalized to U6 RNA (internal control).