The Protective Effect of Bosentan against Atherosclerosis in Apolipoprotein E-Deficient Mice Is Mediated by miRNA-21

Table 2

Effect of bosentan on the blood lipid concentrations in mice.

Group	n	Blood lipid concentrations (mmol/L)
		TG	TC	HDL	LDL
Control	10	0.556 ± 0.033	1.740 ± 0.071	1.242 ± 0.057	0.164 ± 0.018
ApoE^–/–	10	1.210 ± 0.129	19.36 ± 1.892	2.760 ± 0.246	5.310 ± 0.560
ApoE^–/– + bosentan	10	1.520 ± 0.338	16.44 ± 1.032	2.554 ± 0.292	4.882 ± 0.329

, compared with the control group; , compared with the ApoE^−/− group; n = 10/group. TG, triglycerides; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein.