Positive Correlation between Activated CypA/CD147 Signaling and MMP-9 Expression in Mice Inflammatory Periapical Lesion

Figure 3

Double immunofluorescence staining of CypA or CD147 with MMP-9. MMP-9 was stained with Dylight488 (green), and CypA or CD147 was stained with CY3 (red). Nuclei were counterstained with DAPI (blue). The distribution of CypA-positive or CD147-positive cells was overlapped with MMP-9-positive cells. The double staining cells were mainly osteoclast, macrophages, and fibroblasts. The arrows indicated the colocalization of CypA or CD147 with MMP-9 on osteoclasts-like cells on the bone surface. Magnification: 400×; Scale bar = 50 μm.