LncRNA HOXA11-AS Promotes Proliferation and Cisplatin Resistance of Oral Squamous Cell Carcinoma by Suppression of miR-214-3p Expression

Figure 3

HOMA11-AS interacted with and negatively regulated miR-214-3p in OSCC cells. (a) Bioinformatics analysis indicated the putative binding sites and corresponding mutant region for HOMA11-AS within miR-214-3p. (b) Effect of miR-214-3p transfection on the luciferase activity of WT-HOMA11-AS and MUT-HOMA11-AS reporter systems was evaluated by dual luciferase reporter assay in 293T cells (p=0.037). (c) miR-214-3p expression in TSCCA-CDDP and CAL-27-CDDP cells transfected by si-HOMA11-AS or its negative control (p=0.039; p=0.031). (d) miR-214-3p expression in TSCCA and CAL-27 cells transfected by pcDNA-HOMA11-AS or its negative control (p=0.011; p=0.014). #P < 0.05.

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