PC-3-Derived Exosomes Inhibit Osteoclast Differentiation by Downregulating miR-214 and Blocking NF-B Signaling Pathway

Figure 4

PC-3-derived exosomes block the NF-κB signaling pathway through miR-214 downregulation. (a) Western blotting of p-p65, p65, p-IKBA, and IKBA in osteoclasts treated with 0, 10, 30, or 50 ng exosomes/1000 cells. (b) Western blotting of p-p65, p65, p-IKBA, and IKBA in osteoclasts transfected with miR-214 mimic or inhibitor or NC after M-CSF and RANKL induction.

(a)

(b)