Atorvastatin Improves Hepatic Lipid Metabolism and Protects Renal Damage in Adenine-Induced Chronic Kidney Disease in Sprague-Dawley Rats

Table 3

Effect of atorvastatin treatment on kidney biochemical parameters after 24 days in the serum and urine of adenine-induced CKD rats.

	CLT	CKD	CKD + ATV
Serum creatinine (mg/dL)	0.45 ± 0.07	2.62 ± 0.08	1.49 ± 0.26
Urine creatinine (mg/dL)	28.69 ± 2.61	11.23 ± 0.34	19.86 ± 0.91
Creatinine clearance (ml/min/kg)	3.07 ± 0.20	0.63 ± 0.13	1.29 ± 0.25
Blood urea nitrogen (mg/dL)	4.46 ± 1.53	13.09 ± 1.19	5.95 ± 0.75
Urine urea nitrogen (mg/dL)	14.28 ± 1.06	5.95 ± 0.75	10.11 ± 1.10
Serum albumin (mg/dL)	8.41 ± 0.32	5.47 ± 0.08	6.70 ± 0.29
Urine protein (mg/24 h)	5.52 ± 0.83	70.73 ± 4.14	9.71 ± 2.60

Values represent the mean ± SEM of 5 to 6 rats (n = 5 to 6). Significant difference from control: and . Significant difference from CKD:, , and . CLT: control; CKD: chronic kidney disease.