Usnea Acid as Multidrug Resistance (MDR) Reversing Agent against Human Chronic Myelogenous Leukemia K562/ADR Cells via an ROS Dependent Apoptosis

<div><i>Effects of UA on cell viability and intracellular accumulation of Adr in K562/ADR cells</i>. Cells were treated with UA(4 <i>μ</i>M), Adr UA(4 <i>μ</i>M), and UA plus Adr (4 <i>μ</i>M, respectively) for 48 hr, medium with same concentration of DMSO was used as control. Adr accumulation was increased by UR observed by confocal microscopy (b) and flow cytometry(a, d). Cell viability was dramatically decrease by UA plus Adr compare with Adr alone(c). Columns, values are expressed as mean ± SD.</div>

BioMed Research International

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Figure 1

Figure 1: Usnea Acid as Multidrug Resistance (MDR) Reversing Agent against Human Chronic Myelogenous Leukemia K562/ADR Cells via an ROS Dependent Apoptosis 

Figure 1 | Usnea Acid as Multidrug Resistance (MDR) Reversing Agent against Human Chronic Myelogenous Leukemia K562/ADR Cells via an ROS Dependent Apoptosis 