Tissue Composition and Biomechanical Property Changes in the Vaginal Wall of Ovariectomized Young Rats

Figure 2

Collagen composition and alignment of the lamina propria layer in the rat vaginal wall. (a) Birefringence images (×200) of Sirius Red-stained tissues showing Group 1 (control group), Group 2 (2 weeks after ovariectomy), Group 3 (4 weeks after ovariectomy), and Group 4 (16 weeks after ovariectomy). The percent area of mature collagen (b) and immature collagen (c) within the lamina propria in the four groups. The data are presented as the mean±SEM of n=6 animals/group. Scale bar represents 100 μm. Significant differences (P<0.05) are denoted ().

(a)

(b)

(c)