A Novel OsteomiRs Expression Signature for Osteoblast Differentiation of Human Amniotic Membrane-Derived Mesenchymal Stem Cells

Figure 4

Model for regulation of osteogenesis by miRNAs impacting TGF-β and WNT/β-catenin pathways. The schema shows a subset of modulated miRNAs at 7 (maturation) and 14 (mineralization) days after the dexamethasone-induced differentiation of AM-hMSCs to osteoblasts relative to control undifferentiated cells (time 0). Selected miRNAs and their predicted targets involved in WNT/β-catenin and TGFβ signaling pathways are depicted. Proteins that stimulate and repress the osteogenic differentiation process are denoted with green and red lines, respectively. Molecular functions of gene targets and corresponding pathways are denoted in colors.