A Novel OsteomiRs Expression Signature for Osteoblast Differentiation of Human Amniotic Membrane-Derived Mesenchymal Stem Cells

Figure 5

Representative miRNA/mRNA interaction network for osteogenic differentiation of hAM-MSCs at mineralization stage. The pairs miRNAs/mRNA in the interaction network were generated based on the expression levels of upregulated miRNAs at mineralization stage (14 days) and their predicted gene targets with known inhibitory functions in the TGF-β pathway. The solid color lines connecting molecules represent miRNA-mRNA interaction. The interaction network showed deregulated subnetworks that are clearly separate depending on the number of targets for each miRNA, for instance, genes potentially modulated by 1-3 upregulated miRNAs (in orange), and others by 4-6 miRNAs (in green).