A Novel OsteomiRs Expression Signature for Osteoblast Differentiation of Human Amniotic Membrane-Derived Mesenchymal Stem Cells

Table 2

MicroRNAs expression profile of hAM-MSCs after 14 days of differentiation to osteoblasts.

Down-regulated	Fold change (log2)	p-value	Chromosomal location
miR-302b-3p	-5.50	0.008	4q25
miR-223-3p	-4.90	0.008	Xq12
miR-126-3p	-4.78	0.007	9q34.3
miR-890	-4.53	0.020	Xq27.3
miR-548a-3p	-4.52	0.017	6p22.3
miR-217	-4.49	0.009	2p16.1
miR-302a-3p	-4.48	0.009	4q25
miR-517a-3p	-4.48	0.009	19q13.42
miR-369-3p	-4.46	0.008	14q32.31
miR-521	-4.41	0.006	19q13.42
miR-335-3p	-3.95	0.008	7q32.2
miR-888-5p	-3.95	0.002	Xq27.3
miR-1-3p	-3.92	0.002	20q13.33
miR-511-5p	-3.82	0.004	10p12.33
miR-518e-3p	-3.79	0.005	19q13.42
miR-141-3p	-3.58	0.004	12p13.31
miR-545-3p	-3.47	0.009	Xq13.2
miR-146b-3p	-3.44	0.008	10q24.32
miR-616-3p	-3.33	0.017	12q13.3
miR-133b	-3.28	0.033	6p12.2
miR-142-5p	-3.27	0.034	17q22
miR-216b-5p	-3.23	0.036	2p16.1
miR-491-3p	-3.19	0.038	9p21.3
miR-371a-3p	-3.10	0.046	19q13.42
miR-142-3p	-2.91	0.020	17q22
miR-127-5p	-2.90	0.022	14q32.2
miR-204-5p	-2.89	0.028	9q21.12
miR-381-3p	-2.89	0.021	14q32.31
miR-570-3p	-2.87	0.020	3q29
miR-202-3p	-2.69	0.043	10q26.3
miR-197-3p	-2.54	0.033	1p13.3
miR-32-5p	-2.50	0.009	9q31.3
miR-138-5p	-2.49	0.005	3p21.32
miR-372-3p	-2.47	0.011	19q13.42
miR-190a-5p	-2.45	0.007	15q22.2
miR-34b-3p	-1.88	0.008	11q23.1
miR-636	-1.56	0.014	17q25.1
miR-539-5p	-1.51	0.001	14q32.31
miR-186-5p	-1.50	0.003	1p31.1
miR-576-3p	-1.50	0.002	4q25
miR-542-3p	-1.50	0.011	Xq26.3
miR-374a-5p	-1.49	0.034	Xq13.2
miR-449b-5p	-1.49	0.012	5q11.2
miR-296-3p	-1.48	0.004	20q13.32
miR-370-3p	-1.46	0.032	14q32.31
miR-409-3p	-0.95	0.02	14q32.31
miR-505-3p	-0.90	0.017	Xq27.1
Up-regulated	Fold change (log2)	p-value	Chromosomal location
miR-136-3p	1.05	0.013	14q32.2
let-7i-3p	1.05	0.018	12q14.1
miR-191-3p	1.06	0.009	3p21.31
miR-337-5p	1.46	0.001	14q32.2
miR-27b-3p	1.46	0.009	9q22.32
miR-21-5p	1.48	0.010	17q23.1
miR-145-5p	1.49	0.001	5q32
miR-503-5p	1.49	0.008	Xq26.3
miR-19b-3p	1.49	0.027	13q31.3
miR-345-5p	1.50	0.006	14q32.2
miR-125b-5p	1.51	0.001	21q21.1
miR-744-5p	1.51	0.003	17p12
miR-20b-5p	1.53	0.005	Xq26.2
miR-143-3p	1.54	0.002	5q32
miR-181a-5p	1.91	0.037	9q33.3
miR-181c-5p	1.93	0.044	19p13.12
miR-181a-3p	2.39	0.023	9q33.3
miR-155-5p	2.50	0.017	21q21.3
miR-27a-3p	2.51	0.001	19p13.12
miR-199a-5p	2.88	0.034	19p13.2
miR-148b-3p	4.73	0.029	12q13.13
miR-431-5p	6.46	0.014	14q32.2
let-7f-5p	6.50	0.019	9q22.32
let-7a-5p	7.89	0.024	9q22.32
miR-22-3p	8.51	0.003	17p13.3

miRNAs previously related to osteogenesis are denoted in bold.