A Novel OsteomiRs Expression Signature for Osteoblast Differentiation of Human Amniotic Membrane-Derived Mesenchymal Stem Cells

Table 3

Cellular signaling pathways regulated by miRNAs regulated at 7 days of differentiation to osteoblasts.

KEGG pathway	p-value	Number of target genes	Number of miRNAs
TGFβ pathway	0.0002	42	17
PI3K-Akt pathway	0.0005	152	20
Hippo pathway	0.0006	68	20
FoxO pathway	0.0013	68	20
Ubiquitin mediated proteolysis	0.0015	67	18
Ras pathway	0.0020	105	21
ErbB pathway	0.0024	46	19
Rap1 pathway	0.0024	98	21
Phosphatidylinositol signaling system	0.0028	43	16
AMPK pathway	0.0062	60	18
mTOR pathway	0.0078	33	18
Signaling pathways regulating pluripotency of stem cells	0.0099	65	20
Focal adhesion	0.0136	92	20
MAPK pathway	0.0259	111	21
Calcium pathway	0.0322	78	17