A Novel OsteomiRs Expression Signature for Osteoblast Differentiation of Human Amniotic Membrane-Derived Mesenchymal Stem Cells

Table 4

Cellular signaling pathways regulated by miRNAs modulated at 14 days of differentiation to osteoblasts.

KEGG pathway	p-value	Number of target genes	Number of miRNAs
ECM-receptor interaction	8.03e-11	63	56
Hippo signaling pathway	2.62e-07	115	64
Focal adhesion	3.11e-07	159	64
ErbB signaling pathway	3.45e-07	72	60
TGF-beta signaling pathway	5.50e-07	63	59
PI3K-Akt signaling pathway	8.54e-07	247	64
Ras signaling pathway	2.29e-05	160	63
Wnt signaling pathway	7.70e-05	105	63
MAPK signaling pathway	0.0002	179	63
Rap1 signaling pathway	0.0002	152	62
Signaling pathways regulating pluripotency of stem cells	0.0004	103	65
Protein processing in endoplasmic reticulum	0.0021	116	59
FoxO signaling pathway	0.0021	96	62
Adherens junction	0.0064	58	55
Ubiquitin mediated proteolysis	0.0123	98	60
mTOR signaling pathway	0.0128	46	58
Gap junction	0.0139	64	60
cGMP-PKG signaling pathway	0.0192	113	63
cAMP signaling pathway	0.0211	134	63
p53 signaling pathway	0.0228	50	55
Notch signaling pathway	0.0430	36	35
AMPK signaling pathway	0.0467	87	61