Review Article
Potential Role of lncRNA H19 as a Cancer Biomarker in Human Cancers Detection and Diagnosis: A Pooled Analysis Based on 1585 Subjects
Table 1
Characteristics of the included studies.
| | First author | Year | Country | Ethnicity | Cancer type | Normalizer | Sample type | Test method | Cutoff | Cases/ controls | TP | FP | FN | TN | QUADAS-2 |
| | Zhang | 2016 | China | Asian | BRC | β-actin | Plasma | qRT-PCR | 1.085 | 97/116 | 56 | 16 | 41 | 100 | 5 | | Zhang | 2016 | China | Asian | BRC | β-actin | Urinary | qRT-PCR | NA | 30/42 | 22 | 14 | 8 | 28 | 4 | | Sun | 2016 | China | Asian | HCC | GAPDH | Serum | qRT-PCR | 0. 073 | 180/211 | 140 | 16 | 40 | 195 | 4 | | Chen | 2016 | China | Asian | GC | GAPDH | tissue | qRT-PCR | 4.615 | 128/128 | 79 | 33 | 49 | 95 | 5 | | Hashad | 2016 | Egypt | African | GC | GAPDH | Plasma | qRT-PCR | 0.5 | 32/30 | 22 | 13 | 10 | 17 | 6 | | Zhang | 2016 | China | Asian | BRC | β-actin | Plasma | qRT-PCR | NA | 102/96 | 58 | 13 | 44 | 83 | 4 | | Zhou | 2015 | China | Asian | GC | GAPDH | Plasma | qRT-PCR | NA | 70/70 | 58 | 19 | 12 | 51 | 5 | | Liu | 2017 | China | Asian | TC | GAPDH | Tissue | qRT-PCR | 3.58 | 131/122 | 95 | 30 | 36 | 92 | 5 |
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BRC: breast cancer; HCC: hepatic carcinoma; GC: gastric cancer; TC: thyroid cancer; NA.: not available; TP: true positive; FP: false positive; FN: false negative; TN: true negative.
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