DNA Methyltransferases in Malar Melasma and Their Modification by Sunscreen in Combination with 4% Niacinamide, 0.05% Retinoic Acid, or Placebo

Figure 2

Epidermal presence of 5-methylcytosine after treatment. Representative comparison of indirect immunofluorescences of melasma skin after 8 weeks of treatment. Treated skin with 4% niacinamide (a) and 0.05% retinoic acid (b) show lower specific staining than placebo (c) (x400).

(a)

(b)

(c)