High-Dose Aspirin Reverses Tartrazine-Induced Cell Growth Dysregulation Independent of p53 Signaling and Antioxidant Mechanisms in Rat Brain

Figure 1

Relative changes in gene expression in the brain of rats in the treatment groups relative to the control group. (a–e) Fold changes in p53 (a), Bcl-xL (b), Ki67 (c), CDK2 (d), and p27 (e) are shown. Data are expressed as mean ± SE. < 0.05, < 0.01, and < 0.001 versus control; ns, nonsignificant. A, 150 mg/kg aspirin; C, control; T, 700 mg/kg tartrazine; TA, tartrazine + aspirin.

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