Evaluation of Sperm Impairing Factor from Serratia marcescens as Male Contraceptive in Mouse Model

Table 1

Seminal parameters of male mice after intratesticular administration of SAF.

Concentration of SAF (µg)

Days

Day 3

Day 7

Day 14

Day 21

Sperm count (×10^6)

Motility (%)

Sperm count (×10^6)

Motility (%)

Sperm count (×10^6)

Motility (%)

Sperm count (×10^6)

Motility (%)

L

R

L

R

L

R

L

R

L

R

L

R

L

R

L

R

10

15 ± 3.60

0

37.3 ± 2.30

0

17.3 ± 3.51

0

40.3 ± 4.02

0

14.6 ± 3.05

11.6 ± 2.08

53.3 ± 3.86

52.6 ± 3.08

15.6 ± 3.21

14.6 ± 1.52

38.3 ± 2.50

36.6 ± 1.15

50

15.6 ± 3.51

0

52 ± 2.55

0

14.6 ± 3.51

0

56.3 ± 4.72

0

12.6 ± 1.15

0

40.6 ± 3.05

0

20.3 ± 6.02

16.6 ± 1.52

43.6 ± 3.05

38.3 ± 2.77

100

22.3 ± 4.16

0

52 ± 4.1

0

17 ± 2

0

45 ± 5.66

0

23 ± 1

0

62 ± 3.05

0

15.3 ± 5.03

0

53 ± 5.02

0

200

21 ± 2.6

0

51 ± 5.03

0

18 ± 3

0

42 ± 5.08

0

19.6 ± 4.16

0

61 ± 6.05

0

18 ± 3

0

48 ± 5.07

0

400

20 ± 2.6

0

42.33 ± 4.13

0

32.3 ± 4.16

0

56.6 ± 2.05

0

26.6 ± 3.21

0

38.6 ± 3.05

0

28.3 ± 3.51

0

36 ± 5.32

0

Concentration of SAF (µg)

Day 30

Day 45

Day 60

Day 90

Sperm count (×10^6)

Motility (%)

Sperm count (×10^6)

Motility (%)

Sperm count (×10^6)

Motility (%)

Sperm count (×10^6)

Motility (%)

L

R

L

R

L

R

L

R

L

R

L

R

L

R

L

R

10

ND

ND

ND

ND

ND

ND

ND

ND

ND

ND

ND

ND

ND

ND

ND

ND

50

19 ± 3.60

18.3 ± 4.16

43.6 ± 3.06

41.6 ± 2.05

ND

ND

ND

ND

ND

ND

ND

ND

ND

ND

ND

ND

100

17 ± 3.6

9.3 ± 2.51

46 ± 2.05

32 ± 3.5

18.6 ± 3.05

18.3 ± 2.08

41 ± 3.5

38 ± 5.08

ND

ND

ND

ND

ND

ND

ND

ND

200

15.6 ± 1.52

0

45 ± 5.3

0

14.6 ± 5.03

0

53 ± 5.4

0

20 ± 4.5

19.6 ± 3.51

57 ± 4.03

53 ± 3.50

ND

ND

ND

ND

400

32.3 ± 2.51

0

49.3 ± 6.05

0

21.6 ± 3.21

0

56.3 ± 3.05

0

18.3 ± 3.78

0

35.3 ± 4.15

0

24 ± 1.73

0

40.3 ± 3.05

0

(Data presented as mean ± SD; L: left side; R: right side; ND: not determined).