Rosmarinic Acid Enriched Fraction from Perilla frutescens Leaves Strongly Protects Indomethacin-Induced Gastric Ulcer in Rats

Figure 6

Effect of pretreatment with EE and AF diminished of the expression of proinflammatory cytokines gene, COX-2 gene, and PGE₂ level on IND-induced gastric ulcer in gastric rats. (a) TNF-α, (b) IL-1β, (c) IL-6, (d) COX-2 mRNA expressions, and (e) serum level of PGE₂. The data are expressed as mean ± SEM (n=6). ^∗∗P < 0.01 vs. NC group. ^#P < 0.05; ^##P < 0.01 vs. IND group.

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