Tripartite Motif Containing 11 Interacts with DUSP6 to Promote the Growth of Human Osteosarcoma Cells through Regulating ERK1/2 Pathway

Figure 2

TRIM11 silencing suppressed the growth of OS cells. (a, b) Cell proliferation was determined in HOS and U2OS at 0 h, 12 h, 24 h, and 48 h after transfecting with siNC, siTRIM11-1, or siTRIM11-2. vs siNC. (c) Knockdown of TRIM11 promoted the apoptosis of HOS and U2OS. vs siNC. (d, e) Western blot was used to examine the protein content of TRIM11, DUSP6, Bcl2, c-fos, p-c-fos, p-ERK1/2, and ERK1/2 in HOS and U2OS cells as indicated above. vs siNC.

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