Tripartite Motif Containing 11 Interacts with DUSP6 to Promote the Growth of Human Osteosarcoma Cells through Regulating ERK1/2 Pathway

Figure 3

The function of TRIM11 was disrupted by the ERK1/2 inhibitor PD98059 in OS cells. (a) The ERK1/2 inhibitor PD98059 suppressed the proliferation rate of oeTRIM11 transfected cells. vs oeNC; vs oeNC; vs oeNC; ^!!! vs oeTRIM11. (b) The ERK1/2 inhibitor PD98059 significantly promoted the apoptosis ratio of oeTRIM11 transfected cells. vs oeNC, vs oeNC; ^!!! vs oeTRIM11. (c) Western blot was performed to determine the protein content of TRIM11, DUSP6, Bcl2, c-fos, p-c-fos, p-ERK1/2, and ERK1/2 in different cells as indicated above. vs oeNC; ^!!! vs oeTRIM11.

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