Inclusion of hnRNP L Alternative Exon 7 Is Associated with Good Prognosis and Inhibited by Oncogene SRSF3 in Head and Neck Squamous Cell Carcinoma

Figure 2

The lower inclusion of hnRNP L exon 7 was confirmed in 61 OSCC cancer samples compared with 23 adjacent normal tissues. (a) The representative RT-PCR results of the alternative splicing of hnRNP L exon 7 in normal or OSCC tissues. HnRNP L-L and hnRNP L-S represent transcripts with or without exon 7, respectively. Diagrams on the right of show the structures of hnRNP L spliced products and primer positions (short lines above or below exons). (b) The scatter dot plot summarized the relative inclusion levels of hnRNP L exon 7 (L/S ratio) in OSCC tumor and normal tissues. (c) The scatter dot plot summarized the relative inclusion levels of hnRNP L exon 7 (L/S ratio) in OSCC tumors with low (28 cases) or high (33 cases) pathological stage.

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