PLCE1 Polymorphisms and Risk of Esophageal and Gastric Cancer in a Northwestern Chinese Population
Table 2
Logistic regression of candidate tSNPs in PLCE1 and their association with EC and GC risk.
ID
Genotype
Case (n = 324)
Control (n = 357)
Crude OR
P
Adjusted OR
P
HWE-P
No. (%)
No. (%)
(95%CI)
(95%CI)
rs3765524
CC
168
(51.9)
223
(62.6)
1
1
0.896
CT
136
(42.0)
117
(32.9)
1.54
(1.12-2.12)
0.008
1.66
(1.16-2.38)
0.006
TT
20
(6.2)
16
(4.5)
1.66
(0.83-3.30)
0.149
1.60
(0.72-3.55)
0.247
CT/TT
156
(48.1)
133
(37.4)
1.56
(1.15-2.11)
0.005
1.65
(1.17-2.34)
0.004
rs3818432
CC
104
(57.5)
193
(65.6)
1
1
0.856
CA
73
(40.3)
91
(31.0)
1.49
(1.01-2.20)
0.045
1.47
(0.97-2.23)
0.073
AA
4
(2.2)
10
(3.4)
0.74
(0.23-2.42)
0.622
0.87
(0.24-3.09)
0.826
CA/AA
77
(42.5)
101
(34.4)
1.41
(0.97-2.07)
0.074
1.41
(0.94-2.13)
0.098
rs2274223
AA
177
(54.8)
229
(64.1)
1
1
0.457
AG
126
(39.0)
111
(31.1)
1.47
(1.06-2.03)
0.019
1.57
(1.10-2.26)
0.014
GG
20
(6.2)
17
(4.8)
1.52
(0.77-2.99)
0.223
1.43
(0.66-3.14)
0.367
AG/GG
146
(45.2)
128
(35.9)
1.48
(1.08-2.01)
0.013
1.55
(1.10-2.20)
0.013
rs10509670
AA
178
(54.9)
229
(64.5)
1
1
0.391
AG
124
(38.3)
109
(30.7)
1.46
(1.06-2.02)
0.021
1.54
(1.07-2.21)
0.019
GG
22
(6.8)
17
(4.8)
1.66
(0.86-3.23)
0.132
1.54
(0.72-3.32)
0.268
AG/GG
146
(45.1)
126
(35.5)
1.49
(1.10-2.03)
0.011
1.54
(1.09-2.18)
0.014
rs11187852
GG
122
(67.4)
212
(72.1)
1
1
0.506
GA
56
(30.9)
77
(26.2)
1.26
(0.84-1.90)
0.263
1.33
(0.85-2.07)
0.212
AA
3
(1.7)
5
(1.7)
1.04
(0.24-4.44)
0.955
1.68
(0.34-8.18)
0.522
GA/AA
59
(32.6)
82
(27.9)
1.25
(0.84-1.87)
0.276
1.34
(0.87-2.08)
0.185
rs3781264
TT
120
(66.3)
206
(70.1)
1
1
0.511
TC
58
(32.0)
82
(27.9)
1.21
(0.81-1.82)
0.347
1.24
(0.80-1.92)
0.331
CC
3
(1.7)
6
(2.0)
0.86
(0.21-3.49)
0.831
1.07
(0.23-5.00)
0.932
TC/CC
61
(33.7)
88
(29.9)
1.19
(0.80-1.77)
0.390
1.23
(0.80-1.89)
0.340
rs11187866
CC
120
(66.7)
210
(71.4)
1
1
0.723
CG
56
(31.1)
76
(25.9)
1.29
(0.85-1.95)
0.226
1.33
(0.85-2.08)
0.210
GG
4
(2.2)
8
(2.7)
0.88
(0.26-2.97)
0.830
1.13
(0.30-4.23)
0.857
CG/GG
60
(33.3)
84
(28.6)
1.25
(0.84-1.86)
0.274
1.31
(0.85-2.03)
0.218
Notes. The adjusted OR is derived from the correction for age and gender. The results were in bold, if the P value < 0.05. EC, esophageal cancer; GC, gastric cancer.
