PLCE1 Polymorphisms and Risk of Esophageal and Gastric Cancer in a Northwestern Chinese Population
Table 4
Stratified analysis for the association between tSNPs in PLCE1 and EC and GC risk.
Variables
rs3765524
Adjusted OR
P
rs2274223
Adjusted OR
P
rs10509670
Adjusted OR
P
(Case/Control)
(Case/Control)
(Case/Control)
CC
CT/TT
(95%CI)
AA
AG/GG
(95%CI)
AA
AG/GG
(95%CI)
Age, years
≤ 53
58/159
55/109
1.34
(0.86-2.10)
0.203
62/161
50/107
1.18
(0.75-1.86)
0.464
63/161
50/105
1.18
(0.75-1.85)
0.478
>53
110/64
101/24
2.56
(1.41-4.64)
0.002
115/68
96/21
2.63
(1.43-4.82)
0.002
115/68
96/21
2.63
(1.43-4.82)
0.002
Sex
Male
130/137
122/74
1.84
(1.19-2.82)
0.006
136/139
116/73
1.72
(1.12-2.64)
0.014
135/139
117/72
1.76
(1.15-2.71)
0.010
Female
38/86
34/59
1.34
(0.74-2.42)
0.339
41/90
30/55
1.25
(0.68-2.28)
0.476
43/90
29/54
1.16
(0.63-2.12)
0.636
Tumor site
EC
25/223
23/133
2.61
(1.22-5.55)
0.013
24/229
23/128
3.01
(1.39-6.50)
0.005
25/229
23/126
1.40
(1.05-1.86)
0.022
CC
11/223
24/133
5.99
(2.28-15.77)
<0.001
12/229
23/128
5.31
(2.09-13.50)
<0.001
12/229
23/126
5.31
(2.09-13.50)
<0.001
NCC
142/223
114/133
1.47
(1.03-2.12)
0.036
152/229
104/128
1.36
(0.95-1.96)
0.098
152/229
104/126
1.36
(0.95-1.96)
0.096
Pathology
Adenocarcinoma
172/223
141/133
1.45
(1.02-2.06)
0.041
181/229
132/128
1.36
(0.95-1.94)
0.092
180/229
133/126
1.38
(0.97-1.97)
0.078
Squamous carcinoma
21/223
20/133
2.23
(1.05-4.72)
0.037
20/229
21/128
2.71
(1.28-5.76)
0.010
20/229
21/126
2.72
(1.28-5.77)
0.009
Differentiation
Poor
85/223
59/133
1.30
(0.85-1.97)
0.222
86/229
58/128
1.33
(0.87-2.03)
0.182
86/229
58/126
1.40
(1.05-1.86)
0.022
Moderate to well
92/223
83/133
1.72
(1.07-2.76)
0.026
97/229
78/128
1.61
(1.00-2.58)
0.050
96/229
79/126
1.67
(1.04-2.68)
0.034
Tumor size
≤ 5 cm
104/223
100/133
1.81
(1.20-2.72)
0.005
114/229
90/128
1.59
(1.05-2.39)
0.027
115/229
89/126
1.54
(1.02-2.32)
0.039
> 5 cm
58/223
43/133
1.44
(0.88-2.34)
0.148
60/229
41/128
1.39
(0.85-2.27)
0.192
60/229
41/126
1.40
(0.85-2.28)
0.183
Tumor stage
I-II
129/223
115/133
1.60
(1.09-2.33)
0.016
136/229
108/128
1.50
(1.03-2.19)
0.036
137/229
107/126
1.47
(1.01-2.15)
0.047
III-IV
45/223
32/133
1.38
(0.79-2.40)
0.262
47/229
30/128
1.35
(0.77-2.36)
0.297
45/229
32/126
1.53
(0.88-2.68)
0.134
Notes. The adjusted OR is derived from the correction for age and gender. The results were in bold, if the P value < 0.05. EC, esophageal cancer; GC, gastric cancer; CC, cardia cancer; NCC, noncardia cancer.
