Research Article
Carbapenem-Resistant Klebsiella pneumoniae Infections among ICU Admission Patients in Central China: Prevalence and Prediction Model
Table 1
Demographics and clinical characteristics of CRKP and CSKP groups.
| | Characteristics | CRKP | CSKP | P value | | (n, % / mean±SD) | n=244 | n=263 |
| | Age, yrs | 50.6±17.4 | 48.2±19.3 | 0.149 | | Gender (male) | 132 (54.1) | 135 (51.3) | 0.533 | | BMI | 23.1±4.2 | 24.29±5.9 | 0.372 | | Comorbidity | | | | | Diabetes mellitus | 42 (17.2) | 40 (15.2) | 0.54 | | Chronic renal failure | 30 (12.3) | 41 (15.6) | 0.286 | | Chronic pulmonary disease | 84 (34.4) | 65 (24.7) | 0.016 | | Hematologic disease | 12 (4.92) | 14 (5.32) | 0.836 | | Nervous system disease | 26 (10.7) | 35 (13.3) | 0.359 | | Charlson comorbidity index score ⩾3 | 68 (27.9) | 53 (22.1) | 0.131 | | APACHE II score ⩾15 | 156 (63.9) | 83 (31.6) | <0.001 | | SOFA score | 4.1±1.5 | 3.7±1.7 | 0.103 | | Therapeutic devices and procedures performed | | | | | Surgery | 74 (30.3) | 66 (25.1) | 0.188 | | Blood transfusion | 21 (8.6) | 12 (4.6) | 0.065 | | Endoscopy | 7 (2.87) | 11 (4.18) | 0.429 | | Bronchoscopy | 72 (29.1) | 51 (19.4) | 0.007 | | Hemodialysis | 23 (9.4) | 31 (11.8) | 0.389 | | Invasive mechanical ventilation ⩾ 48 h | 86 (35.2) | 50 (19.1) | <0.001 | | Central venous catheter ⩾ 48 h | 186 (76.2) | 175 (66.5) | 0.016 | | Urethral catheter⩾ 48 h | 117 (47.9) | 136 (51.7) | 0.398 | | Parenteral nutrition ⩾ 48 h | 94 (38.5) | 37 (14.1) | <0.001 | | Hospitalization ⩾ 48 h in preceding 90 days | 32 (13.1) | 41 (15.6) | 0.428 | | KP colonization or infection in the preceding year | 42 (17.2) | 16 (6.1) | <0.001 | | Other resistant bacteria colonization or infection in the preceding year | 37 (15.2) | 11 (4.2) | <0.001 | | Bedridden | 21 (8.6) | 19 (7.2) | 0.564 | | Residence of nursing home | 42 (17.2) | 17 (6.5) | <0.001 | | Nosocomial acquired infection | 92 (37.7) | 41 (15.6) | <0.001 | | Immunosuppressive therapy | 27 (11.1) | 9 (3.4) | <0.001 | | Corticosteroid therapy | 35 (14.3) | 11 (4.2) | <0.001 | | Radiotherapy | 4 (1.5) | 4 (1.5) | 0.803 | | Chemotherapy | 3 (1.2) | 4 (1.5) | 0.921 | | Septic shock | 52 (21.3) | 47 (17.9) | 0.329 | | CD4/CD8 ratio <1 | 67 (27.5) | 21 (7.9) | <0.001 | | Natural killer cell (cells/uL) | 191.3±57.4 | 200.7±54.6 | 0.059 | | B lymphocyte (cells/uL) | 75.6±24.6 | 78.7±30.2 | 0.208 | | T lymphocyte (cells/uL) | 1137.5±202.5 | 1108.8±185.2 | 0.096 | | Th lymphocyte (cells/uL) | 338.9±80.3 | 348.4±82.9 | 0.191 | | Ts lymphocyte (cells/uL) | 304.8±78.4 | 298.5±69.3 | 0.337 | | 30-day mortality | 70 (28.9) | 29 (11.0) | <0.001 |
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CRKP: carbapenem-resistant Klebsiella pneumoniae; CSKP: carbapenem susceptible Klebsiella pneumoniae; BMI: body mass index; APACHE II: acute physiology and chronic health evaluation II; SOFA: sequential organ failure assessment.
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