Review Article

Urolithiasis, Independent of Uric Acid, Increased Risk of Coronary Artery and Carotid Atherosclerosis: A Meta-Analysis of Observational Studies

Table 2

Estimates for the association of urolithiasis and arteriosclerosis risk reported in the included studies.

StudyWith urolithiasisWithout urolithiasisEvents for analysisOR (95% CI)Adjusted confounders
EventsTotalEventsTotalUnadjustedMultivariable

Kim et al. [22]4512363764559728Coronary artery calcification (CAC)1.61 (1.45–1.79)1.36 (1.04–1.79)Age, sex, center, year of screening examination, physical activity, alcohol intake, smoking status, education level, body mass index, family history of cardiovascular disease, total energy intake, glucose concentration, systolic blood pressure, triglyceride, high-density lipoprotein cholesterol, uric acid concentrations, and estimated glomerular filtration rate

Hsi et al. [23]NANANANACoronary artery calcification (CAC)1.32 (0.91–1.92)0.94 (0.61–1.43)Age, gender, race/ethnicity, diabetes status, daily energy intake, body mass index, animal protein consumption, calcium intake, and sodium intake
NANANANACoronary artery calcification (CAC)1.57 (1.03–2.39)1.40 (0.87–2.24)

Shavit et al. [27]22571954Abdominal aortic calcification (AAC)1.16 (0.53–2.51)Age, sex, high BP, diabetes, smoking status, and eGFR

Reiner et al. [20]NANANANAPresence of carotid stenosis and/or upper quartile of bulb/internal carotid IMT1.67 (1.17–2.36)1.29 (0.84–1.98)Age, gender, race, clinic status, smoking, treated hypertension, systolic BP, BMI, LDL-cholesterol, HDL-cholesterol, eGFR, uric acid, and HOMA index

Patil et al. [25]2512016120Carotid artery calcification1.71 (0.86–3.40)

Pirlamarla et al. [24]309672136253Abdominal aortic calcification (AAC)0.73 (0.55–0.98)

Tanaka et al. [26]NANANANAAortic calcification (iliac artery bifurcation)0.85 (0.54–1.35)Age, sex, BMI, presence of comorbidities, urine protein, CKD stage, and serum uric acid

Fabris et al. [21]1542542Abnormal arterial stiffness (AAS) (CR-PWV, CF-PWV above 90% of the sample distribution)4.11 (1.33–12.69)3.63 (1.29–10.20)Age, sex, and body mass index (BMI); models with measures of arterial stiffness as dependent variables were further adjusted for MAP, PP, and heart rate (HR)

NA, not available; OR, odds ratio; CI, confidence interval; CR-PWV, carotid-radial pulse-wave velocity; CF-PWV, carotid-femoral pulse-wave velocity.