Association between a TCF4 Polymorphism and Susceptibility to Schizophrenia

Table 1

Allele and genotype frequencies of single SNP association analyses.

Markers	Allele freq (%)		HWE	value^a	OR (95% CI)	Genotype (N)			Model	OR (95% CI)	value^a
SNP ID
rs8766	C	T				CC	CT	TT
SCZ	49.4	50.6	0.067	0.541	1.055	110	216	115	Add	1.052 (0.890–1.244)	0.552
CTR	48.1	51.9			(0.888–1.254)	158	288	182	Dom	1.157 (0.880–1.521)	0.297
									Rec	0.989 (0.746–1.309)	0.936
rs1261085	C	T				CC	CT	TT
SCZ	34.6	65.4	0.215	0.289	1.104	59	186	194	Add	1.100 (0.919–1.316)	0.299
CTR	32.4	67.6			(0.919–1.325)	68	268	287	Dom	1.079 (0.844–1.379)	0.545
									Rec	1.267 (0.873–1.839)	0.213
rs2958182	A	T				AA	AT	TT
SCZ	10.8	89.2	0.641	0.731	0.953	5	85	351	Add	0.952 (0.721–1.258)	0.729
CTR	11.2	88.8			(0.723–1.255)	6	129	492	Dom	0.935 (0.692–1.261)	0.658
									Rec	1.187 (0.360–3.914)	0.778
rs12966547	G	A				GG	AG	AA
SCZ	43.0	57.0	0.492	0.735	1.030	84	212	146	Add	1.030 (0.867–1.123)	0.738
CTR	42.3	57.7			(0.866–1.226)	115	299	212	Dom	1.038 (0.802–1.344)	0.776
									Rec	1.043 (0.763–1.424)	0.793

SCZ: schizophrenia; CTR: control; SNP: single nucleotide polymorphism; Add: additive model; Dom: dominant model; Rec: recessive model; CI: confidence interval; OR: odds ratio; : values of the normal chi-square statistics; HWE: Hardy–Weinberg equilibrium.