A High-Fat Diet Exacerbates the Course of Experimental Trypanosoma cruzi Infection That Can Be Mitigated by Treatment with Simvastatin

Table 1

Nutritional composition in 1 kilogram of diet.

Ingredients	Normolipidic diet (grams)	High-fat diet (grams)
Starch	619.4	249.4
Lard	-	320.0
Casein	14.0	190.0
Coline	2.5	2.5
Fiber	50.0	50.0
L-Cystine	3.0	3.0
Mineral mix	35.0	35.0
Vitamin mix	10.0	10.0
Soy oil	40.0	40.0
Sucrose	100.0	100.0
Total caloric value (kilocalories-kcal)	4,447.4	5,917.5

(I) Mineral mix (expressed in g/kg of the mixture): NaCl-139.3/KI-0.79/MgSO₄·7H₂O-57.3/CaCO₃-381.4/MnSO₄·H₂O-4.01/FeSO₄ ·7H₂O–0.548/CuSO4·5H2O–0.477/CoCl₂·6H₂O–0.023/KH₂PO₄–389.0. (II) Vitamin mix (expressed in mg/kg of the mixture): retinol acetate–690.0/cholecalciferol-5,-/p-amino benzoic acid-10.0/inositol-10.0/niacin-4000.0/riboflavin-800.0/thiamine HCL-500.0; folic acid- 200.0/biotin-40.0/cyanocobalamin-3.0/dl-α-tocopherol-6.7/sucrose -q.s.p.1000.0. (III) BHT (Tert-Butylhydroquinone)-0.008 g to both diets/Kg Added 1% of SIGMA® cholesterol conversion factors: proteins 4.0 kcal/g, lipids 9,0 kcal/g, sugars 4,0 kcal/g.