Exosomal miR-22-3p Derived from Chronic Rhinosinusitis with Nasal Polyps Regulates Vascular Permeability by Targeting VE-Cadherin

Figure 4

Effects of miR-22-3p on vascular permeability by targeting VE-cadherin. (a) The representative fluorescence figure of HUVECs transfected with VE-cadherin. (b, c) Interference efficiency of VE-cadherin was detected by western blot. One-way ANOVA. and . (d) Effects of VE-cadherin on permeability. sh-VE-cad-1 vs. sh-NC. Two-way ANOVA. and . (e, f) HUVECs treated as indicated and analyzed by western blot and (g) qRT-PCR. One-way ANOVA. and . (h) In vitro permeability assays were performed to measure the effects of miR-22-3p on tubule permeability of HUVECs by targeting VE-cadherin. miR-22-inhibitor+sh-VE-cad-1 vs. miR-22-inhibitor-NC. Two-way ANOVA. . Data are presented as of at least three independent experiments.

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