Research Article
Adipose Insulin Resistance and Circulating Betatrophin Levels in Women with PCOS
Table 3
Clinical characteristics, laboratory parameters, and adipose IR levels before and after treatment with metformin in PCOS women.
| | Variable | Baseline | Posttreatment 3 months | Posttreatment 6 months |
| | Betatrophin (μg/L) | 0.53 (0.41–0.62) | 0.3 (0.2–0.42) | 0.35 (0.28–0.38) | | BMI (kg/m2) | 24.0 (22.5–26.3) | 23.0 (21.4–26.5) | 22.4 (21.0–25.3) | | SBP | 115.0 (110.0–120.0) | 114.5 (109.0–120.0) | 118.0 (107.0–121.0) | | DBP | 75.5 (70.0–80.0) | 78.5 (76.0–81.0) | 78.0 (74.0–81.0) | | WHR | 0.86 (0.81–0.90) | 0.87 (0.82–0.91) | 0.85 (0.83–0.92) | | M value (mg/kg/min) | 4.9 (3.5–6.0) | 5.6 (4.4–7.3) | 6.3 (5.0–8.7) | | FBG (mmol/L) | 4.90 (4.47–5.44) | 4.60 (4.29–4.81) | 4.54 (4.33–4.89) | | 2h-BG (mmol/L) | 7.50 (6.19–8.80) | — | 6.90 (5.74–8.85) | | FIns (mU/L) | 16.1 (9.0–20.5) | 12.7 (9.0–19.5) | 10.9 (7.4–16.8) | | 2h-ins (mU/L) | 126.5 (89.4–167.2) | — | 112.2 (77.9–161.5) | | SHBG (nmol/L) | 32.1 (20.4–40.6) | 40.0 (21.5–69.0) | 59.4 (42.8–103.0)∆ | | DHEA-S (μg/dl) | 210.3 (157.4–264.7) | 202.95(170.3–260.8) | 191.25 (144.3–213.2)▲ | | TEST(noml/L) | 2.78 (2.18–3.43) | 2.74 (1.81–3.36) | 2.52 (1.38–2.90) | | LH (IU/l) | 8.77 (4.79–12.66) | 7.9 (4.58–10.10) | 7.29 (5.22–8.50) | | FSH (IU/l) | 7.37 (6.63–8.97) | 7.01 (6–8.39) | 7.69 (5.78–8.34) | | PRL(mIU/L) | 314.18 (228.32–498.41) | 320.01 (233.41–430.57) | 323.19 (260.76–381.60) | | FAI | 9.19 (6.22–11.49) | 5.53 (3.44–13.71) | 3.89 (1.71–6.08)∆ | | TG (mmol/L) | 1.54 (0.89–2.49) | 0.89 (0.68–1.40) | 0.96 (0.61–1.44) | | TC (mmol/L) | 4.46 (3.81–4.81) | 3.99 (3.54–4.46) | 3.88 (3.56–4.61) | | HDL-C (mmol/L) | 1.24 (1.07–1.38) | 1.26 (1.1–1.52) | 1.21 (1.12–1.49) | | LDL-C (mmol/L) | 2.40 (1.97–3.12) | 2.17 (1.68–2.59) | 2.11 (1.78–2.46) | | FFA (μmol/L) | 0.62 (0.50–0.81) | 0.52 (0.38–0.61) | 0.54 (0.42–0.64) | | HOMA-IR | 3.61 (1.71–4.8) | 2.65 (1.70–3.85) | 2.31 (1.35–3.21) | | AUCglucose | 16.3 (14.1–19.0) | 16.5 (15.0–18.7) | 15.0 (13.7–16.9)∆ | | AUCinsulin | 207.3 (147.4–294.9) | 189.1 (142.4–253.0) | 171.3 (114.9–230.8) | | VAIfemale | 2.09 (1.35–3.31) | 1.47 (0.88–2.22) | 1.24 (1.01–1.81) | | BAI | 30.3 (27.3–32.9) | 28.9 (25.6–31.8) | 27.8 (26.1–30.4)▲ | | Adipose IR | 64.4 (28.3–108.2) | 37.8 (28.2–70.8) | 41.0 (24.2–60.5) |
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, compared with baseline; , compared with posttreatment 3 months. |
