Gold Nanoparticles Enhance EGFR Inhibition and Irradiation Effects in Head and Neck Squamous Carcinoma Cells

Figure 4

(a) Adding AuNPs and AG1478 and/or irradiation significantly inhibited cell proliferation. Cell Counting Kit-8 assay shows the combination of 1 nM AuNP+0.5 μM AG1478 inhibited HNSCC cell proliferation, both with and without 4 Gy irradiation. -axis values indicate percentages, with the control as 100%. Data represent three independent experiments and are presented as . AuNPs: gold nanoparticles. (b) Adding AuNPs and/or AG1478 significantly enhanced the apoptotic effect of irradiation. The effects of combining 1 nM AuNPs+0.5 μM AG1478 on apoptosis in HNSCC cells, with or without 4 Gy irradiation, significantly increased the percentage of capase-3⁺ (apoptotic) cells compared with 4 Gy irradiation alone. -axis values are expressed as percentages, with the control as 100%. The data represent three independent experiments and are presented as .

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