BioMed Research International

Research Article

Pressure-Controlled Ventilation-Volume Guaranteed Mode Combined with an Open-Lung Approach Improves Lung Mechanics, Oxygenation Parameters, and the Inflammatory Response during One-Lung Ventilation: A Randomized Controlled Trial

Table 3

Ventilatory parameters, respiratory system mechanics, blood gas, and oxygenation parameters.


	PCV+OLA ()	PCV ()	VCV+OLA ()	VCV ()

(mL)
T₁	432.00 (405.00, 475.00)	429.50 (404.50, 499.75)	445.00 (399.50, 502.00)	449.50 (410.25, 503.25)	0.841
T₂					0.451
T₃	431.00 (408.00, 500.50)	442.50 (411.50, 502.00)	452.00 (405.00, 503.00)	441.00 (407.00, 507.25)	0.936
PEEP (cmH₂O)
T₁	5.00	5.00	5.00	5.00	—
T₂	8.00 (8.00, 10.00)^▲	5.00	10.00 (8.00, 12.00)^▲	5.00	<0.001
T₃	8.00 (8.00, 10.00)^▲	5.00	10.00 (8.00, 12.00)^▲	5.00	<0.001
₍cmH₂O)
T₁					0.255
T₂	21.00 (20.00, 22.00)^△▲	22.00 (19.25, 23.00)^△▲	24.00 (23.00, 25.00)	23.00 (21.00, 25.00)	<0.001
T₃					<0.001
₍cmH₂O)
T₁	10.00 (9.00, 11.00)	10.00 (9.00, 11.00)	10.00 (9.00, 11.00)	10.00 (9.00, 11.00)	0.245
T₂	13.00 (12.00, 13.00)^▲	11.00 (10.00, 12.00)	12.00 (12.00, 14.00)^▲	11.00 (10.00, 12.00)	<0.001
T₃	12.00 (11.00, 13.00)^▲	11.00 (10.00, 12.00)	12.00 (11.00, 13.00)^▲	10.00 (8.00, 11.00)	<0.001
Cdyn (mL/cmH₂O)
T₁					0.943
T₂	27.00 (24.00, 32.00)^▲	23.00 (21.00, 25.00)	27.00 (22.00, 30.00)^▲	20.00 (18.75, 21.00)	<0.001
T₃	^▲	^▲	^▲		0.001
PaCO₂ (mmHg)
T₁					0.345
T₂					0.485
T₃	43.00 (39.50, 47.00)	45.00 (41.00, 47.00)	46.00 (41.00, 48.00)	44.00 (41.00, 47.25)	0.455
pH
T₁					0.402
T₂	7.38 (7.35, 7.40)	7.38 (7.35, 7.42)	7.37 (7.39, 7.40)	7.38 (7.35, 7.41)	0.633
T₃					0.796

T₁					0.210
T₂	^▲		^▲		0.003
T₃	0.16 (0.13, 0.21)^▲	0.20 (0.17, 0.24)	0.19 (0.14, 0.22)	0.21 (0.17, 0.24)	<0.001
Qs/Qt
T₁					0.873
T₂	0.17 (0.16, 0.19)^▲	0.19 (0.18, 0.20)	0.18 (0.17, 0.19)	0.19 (0.17, 0.20)	0.006
T₃					0.280
PaO₂/FiO₂ ratio
T₁					0.875
T₂	173.75 (138.13, 221.87)^▲	153.13 (109.38, 185.94)	166.25 (146.25, 200.63)^▲	134.38 (106.25, 180.63)	0.002
T₃					0.264

Data are expressed as (SD) or median (interquartile range). : tidal volume; T₁: total-lung ventilation 10 min after induction; T₂: one-lung ventilation 45 min; T₃: total-lung ventilation 10 min after one-lung ventilation; PEEP: positive end-expiratory pressure; : peak airway pressure; : mean airway pressure; Cdyn: dynamic compliance; PaCO₂: partial pressure of arterial carbon dioxide; : dead space fraction; Qs/Qt: intrapulmonary shunt ratio; PaO₂/FiO₂: arterial partial pressure of oxygen/fraction of inspired oxygen. versus PCV, ^△ versus VCV+OLA, and ^▲ versus VCV.