Nomogram for Individualized Prediction of Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis on Conservative Treatment

Table 2

Univariate and multivariate Cox regression analyses for overall survival of HCC with PVTT in the derivation cohort.

Variable	Univariate Cox			Multivariate Cox
	HR	95% CI	value	HR	95% CI	value
Median age	0.994	(0.975–1.013)	0.550
Gender	0.936	(0.725–1.208)	0.610
HBV related	1.130	(0.609–2.097)	0.699
Cirrhosis	1.015	(0.776–1.327)	0.923
Comorbidity index	0.980	(0.810–1.180)	0.802
ALT ≥ 70 IU/L	2.006	(1.411–2.852)	<0.001
AST ≥ 119 IU/L	2.849	(2.003–4.053)	<0.001	1.766	(1.194–2.611)	0.004
GGT ≥ 115 IU/L	2.679	(1.727–4.155)	<0.001	2.037	(1.265–3.279)	0.003
Child–Pugh class C	2.955	(1.958–4.459)	<0.001	3.294	(2.075–5.227)	<0.001
WBC ≥ 4.3 × 10^9/L	2.075	(1.394–3.088)	<0.001
Cr ≥ 91 μmoI/L	1.757	(1.099–2.808)	0.018	2.578	(1.573–4.223)	<0.001
Portal vein invasion Vp4	0.890	(0.613–1.290)	0.537
AFP ≥ 400 ng/ml	1.900	(1.335–2.703)	<0.001	1.545	(1.073–2.227)	0.020
Tumor number ≥ 3	1.491	(1.041–2.135)	0.029
Largest tumor diameter ≥ 5 cm	2.129	(1.436–3.157)	<0.001	2.784	(1.804–4.296)	<0.001
Lymph node metastasis	0.942	(0.579–1.532)	0.809

HR, hazard ratios; CI, confidence interval.