Host Genetic and Environmental Factors Shape the Composition and Function of Gut Microbiota in Populations Living at High Altitude
Table 3
Top 10 abundant COGs of the gut microbiota in the Hans.
#COG
Sum (%)
Description
NOG00099
2,936,314 (19.64)
TonB-dependent receptor plug
COG3250
2,051,906 (13.72)
Hydrolase family 2
COG0841
1,867,100 (12.49)
Acriflavin resistance protein
COG0534
1,378,376 (9.22)
Mate efflux family protein
COG1472
1,338,522 (8.95)
Hydrolase family 3
COG0550
1,248,452 (8.35)
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (by similarity)
