Enhancement of Chemokine mRNA Expression by Toll-Like Receptor 2 Stimulation in Human Peripheral Blood Mononuclear Cells of Patients with Atopic Dermatitis

Table 1

The receptors and function properties of chemokines in atopic dermatitis.

Chemokines	Another names	Original cells	Receptors	Target cells	Key functions
CCL5	RANTES	Eosinophil, keratinocyte, LC	CCR1, CCR3, CCR5	Eosinophil, fibroblast, T cell	Eosinophil migration
CCL8	MCP-2	Fibroblast, monocyte	CCR1, CCR2, CCR3, CCR5 (human), CCR8 (mouse)	Basophil, eosinophil, DC precursor, monocyte, Th2 cell	Th2 response, eosinophil migration
CCL13	MCP-4	Endothelial cell, epithelial cell, keratinocyte, monocyte, T cell	CCR2, CCR3, CCR5	Eosinophil, DC precursor, monocyte, T cell	Th2 response, eosinophil migration
CCL17	TARC	DC, endothelial cell, fibroblast, keratinocyte	CCR4, CCR8	Th2 cell, Treg cell	Th2 response, Th2 cell migration
CCL18	PARC, DC-CK1	DC/LC, keratinocyte, monocyte	CCR8	DC precursor, T cell	Th2 response, skin homing of T cell
CCL22	MDC	DC, monocyte	CCR4	Th2 cell, Treg cell	Th2 response, Th2 cell and DC migration