Autophagic Network Analysis of the Dual Effect of Sevoflurane on Neurons Associated with GABARAPL1 and 2

Figure 5

Subnetwork analysis of proteins enriched in candidate signaling. PPI subnetwork was constructed using proteins included in the GABAergic synapse, calcium signaling, and the cAMP signaling pathway with the first neighbor interacted proteins. Node color was mapped to different kinds of proteins. Green presented DPTs of sevoflurane. Orange meant DPT-associated proteins. Purple showed the proteins enriched in GABAergic synapse, calcium signaling, and cAMP signaling. Edge size was mapped to experimentally determined interactions with low values to small size, and edge color was mapped to the combined score with low values to bright colors. Blue arrow indicated target. Pink diamond showed source (a). Flow diagram of screening candidate DPT-associated genes (b).

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