Autophagic Network Analysis of the Dual Effect of Sevoflurane on Neurons Associated with GABARAPL1 and 2

Table 2

Identification of direct protein targets of sevoflurane using DTome.

Searched_Drug (1/1)			Target (8)		Action
Number	DB_ID	Name	Target_Symbol	UniProt ID
1	DB01236	Sevoflurane	GABRA1	P14867	Agonist
2	DB01236	Sevoflurane	GLRA1	P23415	Agonist
3	DB01236	Sevoflurane	GRIA1	P42261	Antagonist
4	DB01236	Sevoflurane	KCNA1	Q09470	Inducer
5	DB01236	Sevoflurane	ATP2C1	P98194	Inhibitor
6	DB01236	Sevoflurane	ATP5D	P30049	Other/unknown
7	DB01236	Sevoflurane	MT-ND1	P03886	Unknown
8	DB01236	Sevoflurane	GABRA1/2/3/4/5/6	P14867/P47869/P34903/P48169/P31644/Q16445	PAM
8	DB01236	Sevoflurane	GABRB1/2/3, GABRD, GABRE	P18505/P47870/28472, Q14764, P78334	PAM
8	DB01236	Sevoflurane	GABRG1/2/3, GABRP, GABRQ	Q8N1C3/P18507/Q99928, O00591, Q9UN88	PAM

GABRA1: gamma-aminobutyric acid receptor subunit alpha-1; glycine receptor subunit alpha-1; glutamate receptor 1; potassium voltage-gate channel subfamily A member 1; calcium-transporting ATPase type 2C member 1; ATP synthase subunit delta, mitochondrial; NADH-ubiquinone oxidoreductase chain 1; GABA-A receptor (anion channel); PAM: positive allosteric modulator.