Recurrence-Associated Multi-RNA Signature to Predict Disease-Free Survival for Ovarian Cancer Patients

Table 2

The most optimal signature combination.

Type	Symbol	Expression		Univariate Cox regression analysis			LASSO coefficient
		logFC	FDR	HR	95% CI	p value
miRNA	Hsa-miR-506	−1.01	3.91E − 02	0.94	0.88–0.99	0.014	−0.20
Coding	MAGI3	−0.71	1.15E − 02	0.56	0.41–0.78	0.001	−0.27
Coding	SLAMF7	−0.99	4.43E − 02	0.75	0.62–0.92	0.005	−0.29
Coding	GLI2	−0.85	3.58E − 02	0.74	0.59–0.93	0.010	−0.12
Coding	PDK1	−0.72	3.93E − 02	0.66	0.47–0.91	0.011	−0.08
Coding	ARID3A	−0.84	2.99E − 02	0.72	0.55–0.94	0.017	−0.02
Coding	PLEKHG4B	−0.79	1.25E − 02	0.80	0.65–0.97	0.027	−0.03
miRNA	Hsa-miR-508	−0.76	4.84E − 02	1.32	1.02–1.75	0.048	0.12
lncRNA	TM4SF1-AS1	0.99	2.88E − 03	1.28	1.01–1.62	0.037	0.04
Coding	TNFAIP8L3	0.89	6.30E − 03	2.082	1.37–3.16	0.001	0.29
Coding	C1QTNF3	0.85	1.70E − 02	1.331	1.11–1.59	0.002	0.13
Coding	NDUFAF1	0.65	2.24E − 03	1.791	1.22–2.62	0.003	0.15
Coding	CH25H	0.90	4.70E − 02	1.39	1.05–1.83	0.019	0.16
Coding	TMEM129	0.60	1.41E − 02	1.410	1.04–1.92	0.028	0.14

LASSO, least absolute shrinkage and selection operator; FC, fold change; FDR, false discovery rate; HR, hazard ratio; CI, confidence interval.