Recurrence-Associated Multi-RNA Signature to Predict Disease-Free Survival for Ovarian Cancer Patients

Table 3

Univariate and multivariable Cox regression analyses with clinical features.

Variables	Univariate analysis			Multivariate analysis
	HR	95% CI	p value	HR	95% CI	p value
Training set (N = 161)
Age (years, mean ± SD)	1.015	0.997–1.032	9.56E − 02	—	—	—
Neoplasm histologic grade (G2/G3/-)	1.639	0.950–2.828	7.27E − 02	—	—	—
Pathologic stage (II/III/IV/-)	1.713	1.172–2.505	5.68E − 03	1.473	1.189–2.195	4.68E − 02
Lymphovascular invasion (yes/no/-)	1.345	0.693–2.610	3.74E − 01	—	—	—
Vascular invasion (yes/no/-)	1.321	0.614–2.835	4.76E − 01	—	—	—
Risk score status (high/low)	2.905	1.972–4.281	2.12E − 08	2.679	1.809–3.966	8.61E − 07
Testing set (N = 161)
Age (years, mean ± SD)	1.007	0.982–1.014	8.00E − 01	—	—	—
Neoplasm histologic grade (G2/G3/-)	1.107	0.487–1.337	4.04E − 01	—	—	—
Pathologic stage (II/III/IV/-)	1.198	0.662–1.451	9.20E − 01	—	—	—
Lymphovascular invasion (yes/no/-)	1.191	0.464–1.712	7.29E − 01	—	—	—
Vascular invasion (yes/no/-)	1.045	0.451–1.982	8.83E − 01	—	—	—
PS status (high/low)	1.891	1.315–2.721	4.85E − 04	—	—	—
Entire set (N = 322)
Age (years, mean ± SD)	1.006	0.994–1.017	3.41E − 01	—	—	—
Neoplasm histologic grade (G2/G3/-)	1.171	0.809–1.691	4.04E − 01	—	—	—
Pathologic stage (II/III/IV/-)	1.302	1.062–1.701	1.37E − 02	1.114	1.045–1.470	4.43E − 02
Lymphovascular invasion (yes/no/-)	1.093	0.687–1.737	7.08E − 01	—	—	—
Vascular invasion (yes/no/-)	1.125	0.661–1.914	6.64E − 01	—	—	—
Risk score status (high/low)	2.323	1.786–3.022	1.16E − 10	2.259	1.728–2.953	2.49E − 09

HR, hazard ratio; CI, confidence interval; SD, standard deviation. Bold indicates significance.