Diagnostic and Prognostic Values of MANF Expression in Hepatocellular Carcinoma

Table 2

The relationship between MANF status and clinicopathological features of HCC (tissue microarray).

Clinicopathological features	Number of cases ()	MANF expression, (%)		value
		High	Low
Age
≥Median	133	64 (48.1)	69 (51.9)	0.54
<Median	133	69 (51.9)	64 (48.1)
Gender
Male	241	123 (51)	118 (49)	0.293
Female	25	10 (40)	15 (60)
HBV
Positive	245	124 (50.6)	121 (49.4)	0.495
Negative	21	9 (42.9)	12 (57.1)
Cirrhosis
Positive	220	108 (49.1)	112 (50.9)	0.517
Negative	46	25 (54.3)	21 (45.7)
Tumor size
≥5	221	106 (48)	115 (52)	0.141
<5	45	27 (60)	18 (40)
Tumor number
Single	153	73 (47.7)	80 (52.3)	0.385
Multiple	113	60 (53.1)	53 (46.9)
AFP
≥20	201	95 (47.3)	106 (52.7)	0.117
<20	65	38 (58.5)	27 (41.5)
TNM stage
Stage I-II	124	68 (54.8)	56 (45.2)	0.104
Stage III-IV	142	65 (45.8)	77 (54.2)
Differentiation grade
Grade 1-2	182	94 (51.6)	88 (48.4)	0.429
Grade 3-4	84	39 (46.4)	45 (53.6)
Vasoinvasion
Yes	53	28 (52.8)	25 (47.2)	0.645
No	213	105 (49.3)	108 (50.7)
Tumor recurrence
Yes	110	64 (58.2)	46 (41.8)	0.025
No	156	69 (44.2)	87 (55.8)

Notes: ; .