Diagnostic and Prognostic Values of MANF Expression in Hepatocellular Carcinoma

Table 3

Univariate and multivariate analyses of prognostic variables for overall survival in HCC patients.

Clinicopathological features	Univariate analysis			Multivariate analysis
	HR	95% (CI)	value	HR	95% (CI)	value
MANF expression (T)
Low	1.000
High	1.070	0.829-1.380	0.605
MANF expression (NT)
Low	1.000
High	0.896	0.694-1.158	0.401
Age
<Median	1.000
≥Median	1.014	0.786-1.307	0.917
Gender
Male	1.000
Female	0.751	0.470-1.202	0.233
HBV
Negative	1.000
Positive	1.169	0.731-1.870	0.514
Cirrhosis
Negative	1.000
Positive	0.931	0.664-1.304	0.677
Tumor size
<5	1.000
≥5	1.218	0.869-1.705	0.252
Tumor number
Single	1.000			1.000
Multiple	1.442	1.114-1.867	0.005	1.278	0.955-1.710	0.099
AFP
<20	1.000			1.000
≥20	1.360	1.013-1.827	0.041	1.142	0.838-1.555	0.401
TNM stage
Stage I-II	1.000			1.000
Stage III-IV	1.404	1.086-1.814	0.010	0.991	0.726-1.353	0.957
Differentiation grade
Grade 1-2	1.000
Grade 3-4	0.955	0.725-1.260	0.746
Vasoinvasion
No	1.000			1.000
Yes	2.757	1.993-3.813	<0.001	2.521	1.769-3.591	<0.001
Tumor recurrence
No	1.000
Yes	0.815	0.630-1.054	0.119

Notes: ; . T: tumor tissue; NT: nontumor tissue.