CUMS Promotes the Development of Premature Ovarian Insufficiency Mediated by Nerve Growth Factor and Its Receptor in Rats

Figure 5

Morphological alterations in the ovarian tissues of CUMS rats. (a) Control group, there are many normal corpus luteum (★) and large follicles () in ovarian tissue. (b) A close-up section of the image (a) there are many normal small follicles (↓) and medium follicles (←) in ovarian tissue (▲). (c) In the CUMS group, the morphological structure of the ovary shows obvious disorders, including ovarian cortex thickening, ovarian interstitial fibrosis, follicular reduction, and corpus luteum (★) atrophy. (d) A close-up section of image (c), the number of small follicles (↓) decreased, the difference was statistically significant, there were large amounts of atretic large follicles (). (A, C), (b, d). (e) Small follicles in control group and CUMS group. (f) Medium follicles in control group and CUMS group. (g) Large follicles in control group and CUMS group. Values are 10 in the control group and 30 in the CUMS group, respectively. vs. control group. CUMS: chronic unpredictable mild stress.

(a)

(b)

(c)

(d)

(e)

(f)

(g)