Research Article

Influence of Alanine Transaminase Levels on Alpha-Fetoprotein for Predicting Hepatocellular Carcinoma in Patients with Hepatitis B Infection

Table 1

Baseline demographic data of the study population ().

VariableHCC ()Cirrhosis ()Chronic hepatitis ()Healthy group () value value value

Demographic
 Age (years)53.0 (44.0-62.0)53.0 (47.0-62.0)42.0 (34.0-49.0)34.0 (28.0-45.0)0.26<0.001<0.001
 Sex, male221 (92.1%)110 (71.9%)197 (79.4%)109 (69.0%)<0.001<0.001<0.001
Hematological data
 HGB (g/L)139.0 (127.0-151.0)117.0 (97.0-134.0)142.0 (128.0-153.5)151.0 (136.0-158.0)<0.0010.24<0.001
 PLT (109/L)169.9 (120.0-224.0)89.0 (63.5-126.5)180.0 (139.0-229.0)251.0 (217.0-285.5)<0.0010.08<0.001
 PT (s)13.8 (13.3-14.5)16.2 (14.7-18.5)14.4 (13.3-16.9)12.9 (12.4-13.3)<0.001<0.001<0.001
Liver function tests
 AST (IU/L)32.0 (25.0-48.8)49.0 (32.5-74.0)47.5 (27.0-213.5)19.0 (16.0-22.0)<0.001<0.001<0.001
 ALT (IU/L)34.5 (24.0-49.8)35.0 (23.0-56.5)65.5 (27.0-413.8)19.0 (13.8-27.0)0.43<0.001<0.001
 GGT (IU/L)55.5 (32.4-98.0)53.0 (35.0-136.0)47.0 (22.0-161.0)22.0 (16.0-34.0)0.420.20<0.001
 ALP (IU/L)85.0 (67.0-117.3)104.0 (81.0-147.0)86.5 (67.0-123.3)60.0 (48.0-68.0)<0.0010.88<0.001
Tumor markers
 AFP (ng/mL)18.6 (4.8-200.0)5.1 (2.7-12.1)4.6 (1.9-36.5)2.8 (2.0-3.9)<0.001<0.001<0.001
(10-3)#17.6 (4.3-122.0)3.3 (1.3-8.2)1.7 (0.3-4.6)8.6 (3.7-14.1)<0.001<0.001<0.001

Data were presented as median (interquartile range, 25th–75th percentile) or number (percentage). HCC: hepatocellular carcinoma; HGB: hemoglobin; PLT: platelet count; PT: prothrombin time; AFP: alpha-fetoprotein; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; GGT: gamma-glutamyl transferase. #For the convenience of representation, the value of was 1000 times the actual value. value was given for the comparison of the HCC and cirrhosis groups; value was given for the comparison of the HCC and chronic hepatitis groups; value was given for the comparison of the HCC and healthy control groups.