Influence of Alanine Transaminase Levels on Alpha-Fetoprotein for Predicting Hepatocellular Carcinoma in Patients with Hepatitis B Infection
Table 1
Baseline demographic data of the study population ().
Variable
HCC ()
Cirrhosis ()
Chronic hepatitis ()
Healthy group ()
value
value
value
Demographic
Age (years)
53.0 (44.0-62.0)
53.0 (47.0-62.0)
42.0 (34.0-49.0)
34.0 (28.0-45.0)
0.26
<0.001
<0.001
Sex, male
221 (92.1%)
110 (71.9%)
197 (79.4%)
109 (69.0%)
<0.001
<0.001
<0.001
Hematological data
HGB (g/L)
139.0 (127.0-151.0)
117.0 (97.0-134.0)
142.0 (128.0-153.5)
151.0 (136.0-158.0)
<0.001
0.24
<0.001
PLT (109/L)
169.9 (120.0-224.0)
89.0 (63.5-126.5)
180.0 (139.0-229.0)
251.0 (217.0-285.5)
<0.001
0.08
<0.001
PT (s)
13.8 (13.3-14.5)
16.2 (14.7-18.5)
14.4 (13.3-16.9)
12.9 (12.4-13.3)
<0.001
<0.001
<0.001
Liver function tests
AST (IU/L)
32.0 (25.0-48.8)
49.0 (32.5-74.0)
47.5 (27.0-213.5)
19.0 (16.0-22.0)
<0.001
<0.001
<0.001
ALT (IU/L)
34.5 (24.0-49.8)
35.0 (23.0-56.5)
65.5 (27.0-413.8)
19.0 (13.8-27.0)
0.43
<0.001
<0.001
GGT (IU/L)
55.5 (32.4-98.0)
53.0 (35.0-136.0)
47.0 (22.0-161.0)
22.0 (16.0-34.0)
0.42
0.20
<0.001
ALP (IU/L)
85.0 (67.0-117.3)
104.0 (81.0-147.0)
86.5 (67.0-123.3)
60.0 (48.0-68.0)
<0.001
0.88
<0.001
Tumor markers
AFP (ng/mL)
18.6 (4.8-200.0)
5.1 (2.7-12.1)
4.6 (1.9-36.5)
2.8 (2.0-3.9)
<0.001
<0.001
<0.001
(10-3)#
17.6 (4.3-122.0)
3.3 (1.3-8.2)
1.7 (0.3-4.6)
8.6 (3.7-14.1)
<0.001
<0.001
<0.001
Data were presented as median (interquartile range, 25th–75th percentile) or number (percentage). HCC: hepatocellular carcinoma; HGB: hemoglobin; PLT: platelet count; PT: prothrombin time; AFP: alpha-fetoprotein; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; GGT: gamma-glutamyl transferase. #For the convenience of representation, the value of was 1000 times the actual value. value was given for the comparison of the HCC and cirrhosis groups; value was given for the comparison of the HCC and chronic hepatitis groups; value was given for the comparison of the HCC and healthy control groups.