Research Article

Influence of Alanine Transaminase Levels on Alpha-Fetoprotein for Predicting Hepatocellular Carcinoma in Patients with Hepatitis B Infection

Table 2

Univariable and multivariable logistic regression analyses of factors associated with elevated AFP (≥20 ng/mL) in a cohort with chronic hepatitis B and cirrhosis ().

VariableUnivariableMultivariable
OR (95% CI) valueOR (95% CI) value

Age (years)1.00 (0.98, 1.02)0.95
Sex, male2.52 (1.25, 5.11)0.01
AST (IU/L)1.01 (1.00, 1.01)<0.001
ALT (IU/L)1.01 (1.00, 1.01)<0.0011.00 (1.00, 1.01)<0.001
GGT (IU/L)1.01 (1.00, 1.01)<0.0011.00 (1.00, 1.00)0.02
ALP (IU/L)1.01 (1.00, 1.01)0.045
HGB (g/L)1.00 (1.00, 1.01)0.43
PLT (109/L)1.00 (1.00, 1.00)0.09
PT (s)1.08 (1.02, 1.14)0.02

AFP: alpha-fetoprotein; OR: odds ratio; CI: confidence interval; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; GGT: gamma-glutamyl transferase; HGB: hemoglobin; PLT: platelet count; PT: prothrombin time.