Inhibition of MEIS3 Generates Cetuximab Resistance through c-Met and Akt

Figure 3

Colon cancer cell lines (a) LOVO-CON, (b) LOVO MEIS3 shRNA, (c) SNU-61 CON, and (d) SNU-61 MEIS3 were treated with different concentrations of cetuximab for 48 h. The expression of EGFR and p-EGFR was detected by western blotting (). (e) In LOVO-CON and MEIS3 shRNA cells, expression of MEIS3, p-EGFR, and EGFR was detected by western blot (). (f) In SNU-61 CON and SNU-61 MEIS3 cells, the expression of MEIS3, p-EGFR, and EGFR was detected by western blot ().

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