Effect of One-Year Growth Hormone Therapy on Cardiometabolic Risk Factors in Boys with Obesity

Table 2

Change in auxological and cardiovascular metabolic parameters before, during, and after GH treatment.

Variable	Basal	3 months	6 months	9 months	1 year
BMI SDS	2.38 ± 0.39^ab	2.23 ± 0.37	2.06 ± 0.43^c	2.00 ± 0.42	1.77 ± 0.50
IGF-1 (μg/ml)	243.44	676.98	709.43	727.00	818.44
	±124.61^ab	±242.58	±214.72	±186.49	±192.96
TC (mmol/L)	4.53 ± 0.61^b	3.90 ± 0.61	4.02 ± 0.47	3.83 ± 0.51	3.67 ± 0.38
HDL-C (mmol/L)	1.26 ± 0.24	1.35 ± 0.29	1.34 ± 0.30	1.39 ± 0.31	1.49 ± 0.38
LDL-C (mmol/L)	2.76 ± 0.46^ab	2.22 ± 0.36	2.10 ± 0.28^c	2.04 ± 0.42	1.71 ± 0.41
TG (mmol/L)	1.34 ± 0.65^b	1.16 ± 0.55	1.06 ± 0.52	0.92 ± 0.35	0.87 ± 0.35
ALT (U/L) #	31.24 ± 21.85^ab	19.36 ± 9.44	17.29 ± 16.02	15.17 ± 5.60	15.39 ± 4.94
HbA1c (%)	5.68 ± 0.26	5.67 ± 0.28	5.59 ± 0.25	5.62 ± 0.34	5.58 ± 0.26
FBG (mmol/L)	5.24 ± 0.33^b	5.62 ± 0.38	5.65 ± 0.52	5.41 ± 0.48	5.61 ± 0.51
Insulin (μIU/mL)#	24.34 ± 13.52	32.39 ± 13.07	29.06 ± 15.09	24.51 ± 11.51	23.66 ± 12.41
HOMA-IR #	5.67 ± 3.12	8.15 ± 3.60	7.39 ± 4.16	6.02 ± 3.06	5.97 ± 3.12

# value reported for log-transformed values, but values in the table represent a back transformation. when GH treatment of 6 months was compared with baseline. when GH treatment of 1 year was compared with baseline. when GH treatment of 1 year was compared with GH treatment of 6 months.