The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population
Table 2
The distribution of allele frequencies of MIR17HG SNPs in case and control.
SNP ID
Chromosome position
Function
Alleles (minor/major)
MAF
O (HET)
E (HET)
a HWE
OR (95% CI)
b
Case
Control
rs75267932
chr13: 91351812
Exon
G/A
0.104
0.115
0.205
0.204
1.000
0.89 (0.68-1.17)
0.412
rs72640334
chr13: 91352674
Intron
A/C
0.100
0.086
0.164
0.156
0.411
1.19 (0.89-1.60)
0.238
rs7336610
chr13: 91352883
Intron
C/T
0.493
0.489
0.485
0.500
0.489
1.02 (0.86-1.21)
0.826
rs7318578
chr13: 91353215
Intron
C/A
0.289
0.277
0.400
0.401
1.000
1.06 (0.88-1.28)
0.559
rs17735387
chr13: 91353800
Intron
A/G
0.201
0.197
0.311
0.316
0.683
1.03 (0.83-1.27)
0.811
rs1428
chr13: 91354516
Exon
C/A
0.490
0.488
0.484
0.500
0.488
1.01 (0.85-1.19)
0.929
HNSCC: head and neck squamous cell carcinoma; SNP: single nucleotide polymorphisms; MAF: minor allele frequency; HWE: Hardy-Weinberg equilibrium. a values were calculated by exact test, and are excluded; b values were calculated by two-sided , and indicates statistical significance.
