The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population

Table 3

Association of MIR17HG polymorphism with HNSCC risk.

SNP ID	Model	Allele/genotype	Case	Control	With adjusted
					OR (95% CI)
rs75267932
	Allele	A	962	943	1
		G	112	123	0.89 (0.68-1.17)	0.412
	Codominant	AA	433	417	1
		GA	96	109	0.85 (0.63-1.15)	0.297
		GG	8	7	1.10 (0.39-3.06)	0.859
	Dominant	AA	433	417	1
		AG-GG	104	116	0.86 (0.64-1.16)	0.338
	Recessive	AA-AG	529	526	1
		GG	8	7	1.13 (0.41-3.15)	0.812
	Log-additive	–	–	–	0.90 (0.68-1.17)	0.421
rs72640334
	Allele	C	959	973	1
		A	107	91	1.19 (0.89-1.60)	0.238
	Codominant	CC	432	443	1
		CA	95	87	1.12 (0.81-1.54)	0.490
		AA	6	2	3.09 (0.62-15.44)	0.169
	Dominant	CC	432	443	1
		CA-AA	101	89	1.16 (0.85-1.59)	0.344
	Recessive	CC-CA	527	530	1
		AA	0	2	3.04 (0.61-15.14)	0.175
	Log-additive	–	–	–	1.20 (0.89-1.61)	0.235
rs7336610
	Allele	T	544	544	1
		C	530	520	1.02 (0.86-1.21)	0.826
	Codominant	TT	133	143	1
		TC	278	258	1.16 (0.87-1.55)	0.316
		CC	126	131	1.03 (0.73-1.45)	0.856
	Dominant	TT	133	143	1
		TC-CC	404	389	1.12 (0.85-1.47)	0.429
	Recessive	TT-TC	411	401	1
		CC	126	131	0.94 (0.71-1.24)	0.644
	Log-additive	–	–	–	1.02 (0.86-1.21)	0.833
rs7318578
	Allele	A	764	769	1
		C	310	295	1.06 (0.88-1.28)	0.559
	Codominant	AA	267	278	1
		AC	230	213	1.12 (0.87-1.45)	0.360
		CC	40	41	1.02 (0.64-1.62)	0.945
	Dominant	AA	267	278	1
		AC-CC	270	254	1.11 (0.87-1.41)	0.407
	Recessive	AA-AC	497	491	1
		CC	40	41	0.96 (0.61-1.52)	0.875
	Log-additive	–	–	–	1.03 (0.88-1.28)	0.554
rs17735387
	Allele	G	858	856	1
		A	216	210	1.03 (0.83-1.27)	0.811
	Codominant	GG	344	345	1
		GA	170	166	1.03 (0.79-1.33)	0.842
		AA	23	22	1.04 (0.57-1.91)	0.893
	Dominant	GG	344	345	1
		AG-AA	193	188	1.03 (0.80-1.32)	0.825
	Recessive	GG-AG	514	511	1
		AA	23	22	1.03 (0.57-1.88)	0.914
	Log-additive	–	–	–	1.02 (0.83-1.27)	0.822
rs1428
	Allele	A	547	546	1
		C	525	520	1.01 (0.85-1.19)	0.929
	Codominant	AA	137	144	1
		AC	273	258	1.11 (0.83-1.49)	0.464
		CC	126	131	1.01 (0.72-1.42)	0.957
	Dominant	AA	137	144	1
		AC-CC	399	389	1.08 (0.82-1.42)	0.586
	Recessive	AA-AC	410	402	1
		CC	126	131	0.94 (0.71-1.25)	0.670
	Log-additive	–	–	–	1.01 (0.85-1.19)	0.935

HNSCC: head and neck squamous cell carcinoma; CI: confidence interval; OR: odds ratio; SNP: single nucleotide polymorphism. values were calculated by unconditional logistic regression analysis with adjustment for age and gender. indicates statistical significance. Highlighted in bold indicates the significant association between SNPs and HNSCC risk.