The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population
Table 4
The relationship of MIR17HG variants with HNSCC stratified by age and gender.
SNP ID
Allele/genotype
>46 years
≤46 years
Men
Women
OR (95% CI)
OR (95% CI)
OR (95% CI)
OR (95% CI)
rs75267932
A
1
1
1
1
G
1.05 (0.72-1.53)
0.810
0.76 (0.51-1.12)
0.166
0.93 (0.60-1.46)
0.765
0.87 (0.62-1.22)
0.422
AA
1
1
1
1
GA
0.98 (0.64-1.50)
0.937
0.71 (0.45-1.10)
0.125
1.24 (0.75-2.04)
0.407
0.68 (0.46-1.00)
0.050
GG
1.52 (0.36-6.47)
0.570
0.81 (0.18-3.71)
0.790
/
/
3.77 (0.79-17.98)
0.096
AG-GG
1.01 (0.67-1.53)
0.950
0.71 (0.46-1.10)
0.125
1.08 (0.66-1.75)
0.761
0.76 (0.52-1.11)
0.149
rs72640334
C
1
1
1
1
A
1.07 (0.72-1.59)
0.724
1.36 (0.87-2.11)
0.174
0.91 (0.57-1.46)
0.705
1.43 (0.97-2.09)
0.068
CC
1
1
1
1
CA
1.14 (0.75-1.75)
0.536
1.06 (0.65-1.73)
0.814
0.96 (0.58-1.57)
0.858
1.25 (0.82-1.90)
0.295
AA
0.47 (0.04-5.23)
0.539
/
/
/
/
6.37 (0.76-53.39)
0.088
CA-AA
1.12 (0.73-1.70)
0.608
1.20 (0.75-1.93)
0.450
0.93 (0.57-1.53)
0.780
1.35 (0.90-2.04)
0.147
rs7336610
T
1
1
1
1
C
1.07 (0.85-1.35)
0.559
1.13 (0.88-1.45)
0.352
1.19 (0.91-1.57)
0.210
1.15 (0.93-1.43)
0.204
TT
1
1
1
1
TC
1.41 (0.95-2.10)
0.091
1.14 (0.74-1.76)
0.564
1.77 (1.09-2.86)
0.021
1.12 (0.77-1.62)
0.550
CC
1.14 (0.73-1.78)
0.568
1.33 (0.78-2.26)
0.295
1.43 (0.83-2.46)
0.203
1.33 (0.86-2.07)
0.199
TC-CC
1.30 (0.90-1.89)
0.161
1.19 (0.78-1.80)
0.419
1.64 (1.04-2.57)
0.032
1.18 (0.83-1.68)
0.348
rs7318578
A
1
1
1
1
C
1.05 (0.81-1.35)
0.711
1.07 (0.81-1.41)
0.655
0.93 (0.69-1.25)
0.626
1.15 (0.90-1.46)
0.256
AA
1
1
1
1
CA
1.11 (0.79-1.56)
0.561
1.14 (0.79-1.66)
0.487
0.94 (0.63-1.42)
0.776
1.25 (0.91-1.73)
0.166
CC
1.02 (0.54-1.94)
0.944
0.95 (0.48-1.90)
0.894
0.84 (0.40-1.73)
0.634
1.16 (0.63-2.13)
0.642
AC-CC
1.09 (0.79-1.52)
0.591
1.11 (0.78-1.59)
0.568
0.92 (0.63-1.36)
0.692
1.24 (0.91-1.68)
0.171
rs17735387
G
1
1
1
1
A
0.98 (0.74-1.31)
0.894
1.08 (0.79-1.48)
0.622
0.92 (0.65-1.30)
0.649
1.10 (0.84-1.43)
0.510
GG
1
1
1
1
GA
0.94 (0.66-1.34)
0.740
1.17 (0.80-1.73)
0.422
1.00 (0.65-1.53)
0.999
1.04 (0.75-1.45)
0.799
AA
1.04 (0.47-2.33)
0.916
1.09 (0.43-2.78)
0.857
0.68 (0.25-1.84)
0.446
1.36 (0.62-2.96)
0.440
GA-AA
0.95 (0.68-1.34)
0.785
1.16 (0.80-1.69)
0.428
0.96 (0.64-1.44)
0.827
1.08 (0.78-1.48)
0.651
rs1428
A
1
1
1
1
C
1.08 (0.86-1.36)
0.523
1.11 (0.86-1.42)
0.424
1.20 (0.92-1.58)
0.185
1.14 (0.92-1.41)
0.246
AA
1
1
1
1
CA
1.38 (0.93-2.06)
0.112
1.07 (0.70-1.65)
0.750
1.73 (1.07-2.81)
0.025
1.07 (0.74-1.55)
0.713
CC
1.15 (0.74-1.80)
0.533
1.28 (0.75-2.16)
0.367
1.45 (0.84-2.50)
0.180
1.30 (0.84-2.01)
0.239
AC-CC
1.29 (0.89-1.87)
0.177
1.13 (0.75-1.70)
0.573
1.63 (1.04-2.56)
0.035
1.14 (0.81-1.61)
0.463
HNSCC: head and neck squamous cell carcinoma. values were calculated by unconditional logistic regression analysis with adjustment for age and gender. indicates statistical significance. Highlighted in bold indicates the significant association between SNPs and HNSCC risk.
