The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population
Table 5
The relationship of MIR17HG polymorphisms with HNSCC stratified by pathological grade.
SNP ID
Allele/genotype
III-IV ()
I-II ()
OR (95% CI)
rs75267932
A
70
253
1
G
6
27
0.80 (0.32-2.02)
0.641
AA
32
113
1
GA
6
27
/
/
GG
0
0
/
/
AG-GG
6
27
0.65 (0.23-1.86)
0.420
rs72640334
C
66
251
1
A
10
29
1.31 (0.61-2.83)
0.488
CC
28
112
1
CA
10
27
1.90 (0.76-4.71)
0.169
AA
0
1
/
/
CA-AA
10
28
1.84 (0.74-4.55)
0.189
rs7336610
T
33
144
1
C
43
136
1.38 (0.83-2.30)
0.216
TT
8
36
1
TC
17
72
0.98 (0.37-2.60)
0.963
CC
13
32
1.67 (0.58-4.81)
0.342
TC-CC
30
104
1.19 (0.48-2.97)
0.706
rs7318578
A
53
195
1
C
23
85
1.00 (0.57-1.73)
0.987
AA
20
65
1
CA
13
65
0.84 (0.36-1.93)
0.676
CC
5
10
2.25 (0.62-8.16)
0.218
AC-CC
18
75
1.01 (0.47-2.20)
0.973
rs17735387
G
66
223
1
A
10
57
0.59 (0.29-1.23)
0.154
GG
30
92
1
GA
6
39
0.34 (0.12-0.95)
0.040
AA
2
9
0.60 (0.11-3.16)
0.549
GA-AA
8
48
0.38 (0.15-0.97)
0.042
rs1428
A
33
143
1
C
43
135
1.38 (0.83-2.30)
0.215
AA
8
36
1
CA
17
71
0.99 (0.37-2.64)
0.980
CC
13
32
1.69 (0.59-4.87)
0.330
AC-CC
30
103
1.21 (0.48-3.02)
0.684
values were calculated by unconditional logistic regression analysis with adjustment for age and gender. indicates statistical significance. Highlighted in bold indicates the significant association between SNPs and HNSCC risk.
